The team at DNA Labs is excited to be launching our new fertility addition to the LMH-PRO panel. While the causes of infertility are multifactorial, 50% of cases of infertility are estimated to be due to genetic factors. Chromosomal errors are well known to contribute to infertility and early pregnancy loss. In addition, numerous environmental and local factors influence not only DNA repair and replication but healthy gamete production, determining the health and survivability of the embryo. In the fertility section we examine how specific genetic variations influence these factors to impact reproduction in males and females.
What’s included in the report?
There are two new sections to the report, including Fertility specific diet and nutrients and Fertility factors
Fertility specific diet and nutrients:
- Genetic variations alter one’s susceptibility to chronic disease and dietary management. Genetic predispositions give rise to obesity, metabolic disease and diabetes and response to particular dietary regimens, including amounts of total and saturated fat, carbohydrates, and protein to prevent or address the disease process. When it comes to fertility, these metabolic derangements increase oxidative stress within the testes and ovary. In males, this may lead to DNA damage and reductions in sperm count and concentration. In females, insulin resistance and metabolic disease are linked to ovulatory impairment, anovulation, lower ovarian reserves and decrease in fertility rates. The same genes are also linked to pre-pregnancy weight gain and risk for gestational diabetes.
- Understand gene-specific dietary guidelines, including:
- Total and saturated fat levels
- Carbohydrate quantities and forms
- Ideal protein intake
- Gluten and caffeine sensitivity and pregnancy loss
- Nutrients are the foundation to the healthy production of egg and sperm. Genetic variations can alter nutrient absorption, transportation, and metabolism to increase risk for deficiency and increase requirements. Vitamin insufficiencies are associated with male factor infertility and sperm quality, including an increase in DNA fragmentation and aneuploidy. In women, insufficiencies are linked to factors that influence female infertility, including egg quality, hormone balance, ovulatory disturbances, along with fetal and post-partum maternal health.
- Genetic variations can increase the dosage requires for:
- Folate, vitamin B12 – essential for methylation and DNA repair
- Vitamins A, B6, C, D
Fertility Factors – Certain genetic factors may reduce chances of conception and increase the risk for pregnancy complications. In this section understand how specific genetic variations influence the following:
- The influence of oxidative stress and environmental toxics on male infertility
- Genetic predispositions to:
- Clotting disorders
- Susceptibility to dysbiosis and recurrent infections (vaginal candidiasis, recurrent UTIs)
Contact the team at contact@DNAlabs.ca for more information and to get on our contact list to be notified when the panel goes live.